PUBLICATIONS
- Francis Collins -
Original Publications
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Chambers P, Man KKC, Lui VWY, Mpima S, Nasuti P, Forster MD, Wong ICK. Understanding Molecular Testing Uptake Across Tumor Types in Eight Countries: Results From a Multinational Cross-Sectional Survey. JCO Oncol Pract. (2020) Mar 11:JOP1900507. doi: 10.1200/JOP.19.00507 (IF:26.303)
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Wang L and Lui VW. Emerging Roles of ALK in Immunity and Insights for Immunotherapy. Cancers (Basel). (2020); 12(2). pii: E426. doi: 10.3390/cancers12020426 (IF:6.102)
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Tsang CM, Lui VWY, Bruce JP, Pugh TJ, Lo KW. Translational genomics of nasopharyngeal cancer. Semin Cancer Biol (2019); DOI: 10.1016/j.semcancer.2019.09.006. (IF:3.58)
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Xu A, Wang W, Nie J, Lui VW, Hong B, Lin W. Germline mutation and aberrant transcripts of WWOX in a syndrome with multiple primary tumors. J Pathol (2019).249(1):19-25; DOI: 10.1002/path.5288. (IF:6.253)
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Chen Y, Wang X, Fang J, Song J, Ma D, Luo L, He B, Xia J, Lui VWY, Cheng B,Wang Z. Mesenchymal stem cells participate in oral mucosa carcinogenesis by regulating T cell proliferation. Clin Immunol (2019).198:46-53; DOI: 10.1016/j.clim.2018.12.001. (IF: 4.227)
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Qiao W, Lan XM, Ma HX, Chan JYK, Lui VWY, Yeung KWK, Kwong DLW, Hu Z, Tsoi JKH, Matinlinna JP,Su YX. Effects of Salivary Mg on Head and Neck Carcinoma via TRPM7. J Dent Res (2019).98(3):304-312; DOI: 10.1177/0022034518813359. (IF:5.125)
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Wen YH, Lin HQ, Li H, Zhao Y, Lui VWY, Chen L, Wu XM, Sun W,Wen WP. Stromal interleukin-33 promotes regulatory T cell-mediated immunosuppression in head and neck squamous cell carcinoma and correlates with poor prognosis. Cancer Immunol Immunother (2019).68(2):221-232; DOI: 10.1007/s00262-018-2265-2. (IF: 4.846)
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Deng K, Shen J, Wang W, Li M, Li H, Chen C, Zhao H, Zhang M, Xue T, Liu Q, Lui VWY, Hong B,Lin W. Sodium chloride (NaCl) potentiates digoxin-induced anti-tumor activity in small cell lung cancer. Cancer Biol Ther (2019).20(1):52-64; DOI: 10.1080/15384047.2018.1504723. (IF:2.879)
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Zhang L, Li Z, Liu Y, Xu S, Tandon M, Appelboom B, LaValle CR, Chiosea SI, Wang L, Sen M, Lui VWY, Grandis JR,Wang QJ. Analysis of oncogenic activities of protein kinase D1 in head and neck squamous cell carcinoma. BMC Cancer (2018).18(1):1107; DOI: 10.1186/s12885-018-4965-6. (IF:3.288)
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Lan X, She J, Lin DA, Xu Y, Li X, Yang WF, Lui VWY, Jin L, Xie X,Su YX. Microneedle-Mediated Delivery of Lipid-Coated Cisplatin Nanoparticles for Efficient and Safe Cancer Therapy. ACS Appl Mater Interfaces (2018).10(39):33060-33069; DOI: 10.1021/acsami.8b12926. (IF:8.456)
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Ngan HL, Wang L, Lo KW, Lui VWY. Genomic Landscapes of EBV-Associated Nasopharyngeal Carcinoma vs. HPV-Associated Head and Neck Cancer. Cancers (Basel) (2018).10(7); DOI: 10.3390/cancers10070210. (IF:6.162)
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Chan JYK, Poon PHY, Zhang Y, Ng CWK, Piao WY, Ma M, Yip KY, Chan ABW, Lui VWY. Case Report: Exome sequencing reveals recurrent RETSAT mutations and a loss-of-function POLDIP2 mutation in a rare undifferentiated tongue sarcoma. F1000Res (2018).7:499; DOI: 10.12688/f1000research.14383.1. (IF:2.640)
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Song J, Ma D, Liu X, Chen Y, Fang J, Lui VWY, Zhao S, Xia J, Cheng B,Wang Z. Thrombomodulin (TM) in tumor cell differentiation and periphery blood immune microenvironment in oral squamous cell carcinoma. Clin Immunol (2018).191:27-33; DOI: 10.1016/j.clim.2018.02.011. (IF: 4.227)
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Chen L, Wen Y, Zhang J, Sun W, Lui VWY, Wei Y, Chen F,Wen W. Prediction of radiotherapy response with a 5-microRNA signature-based nomogram in head and neck squamous cell carcinoma. Cancer Med (2018).7(3):726-735; DOI: 10.1002/cam4.1369.
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Ng PKS, Lau CPY, Lam EKY, Li SSK, Lui VWY, Yeo W, Ng YK, Lai PBS,Tsui SKW. Hypermethylation of NF-kappaB-Activating Protein-Like (NKAPL) Promoter in Hepatocellular Carcinoma Suppresses Its Expression and Predicts a Poor Prognosis. Dig Dis Sci (2018).63(3):676-686; DOI: 10.1007/s10620-018-4929-3.
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Chen Y, Li Q, Li X, Ma D, Fang J, Luo L, Liu X, Wang X, Lui VWY, Xia J, Cheng B,Wang Z. Blockade of PD-1 effectively inhibits in vivo malignant transformation of oral mucosa. Oncoimmunology (2018).7(2):e1388484; DOI: 10.1080/2162402X.2017.1388484. (IF:3.357)
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Lui VWY, To KF, Lo KW. Genomic profiles of nasopharyngeal carcinoma: The importance of histological subtyping and Epstein-Barr virus in situ assays. Cancer (2018).124(2):434-435; DOI: 10.1002/cncr.31131. (IF:6.162)
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Zhong Q, Liu ZH, Lin ZR, Hu ZD, Yuan L, Liu YM, Zhou AJ, Xu LH, Hu LJ, Wang ZF, Guan XY, Hao JJ, Lui VWY, Guo L, Mai HQ, Chen MY, Han F, Xia YF, Grandis JR, Zhang X, Zeng MS. The RARS-MAD1L1 Fusion Gene Induces Cancer Stem Cell-like Properties and Therapeutic Resistance in Nasopharyngeal Carcinoma. Clin Cancer Res (2018).24(3):659-673; DOI: 10.1158/1078-0432.CCR-17-0352. (IF: 10.199)
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Tsui PC, Lee YF, Liu ZWY, Ip LRH, Piao W, Chiang AKS, Lui VWY. An update on genomic-guided therapies for pediatric solid tumors. Future Oncol (2017).13(15):1345-1358; DOI: 10.2217/fon-2017-0003. (IF: 2.131)
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Wang H, Hong B, Li X, Deng K, Li H, Lui VWY, Lin W. JQ1 synergizes with the Bcl-2 inhibitor ABT-263 against MYCN-amplified small cell lung cancer Oncotarget (2017) Sep 21;8(49):86312-86324. (IF: 5.168)
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Fang J, Li X, Ma D, Liu X, Chen Y, Wang Y, Lui VWY, Xia J, Cheng B,Wang Z. Prognostic significance of tumor infiltrating immune cells in oral squamous cell carcinoma. BMC Cancer (2017).17(1):375; DOI: 10.1186/s12885-017-3317-2. (IF: 3.288)
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Li YY*, Chung GT*, Lui VW*, To KF, Ma BB, Chow C, Woo JK, Yip KY, Seo J, Hui EP, Mak MK, Rusan M, Chau NG, Or YY, Law MH, Law PP, Liu ZW, Ngan HL, Hau PM, Verhoeft KR, Poon PH, Yoo SK, Shin JY, Lee SD, Lun SW, Jia L, Chan AW, Chan JY, Lai PB, Fung CY, Hung ST, Wang L, Chang AM, Chiosea SI, Hedberg ML, Tsao SW, van Hasselt AC, Chan AT, Grandis JR, Hammerman PS,Lo KW. Exome and genome sequencing of nasopharynx cancer identifies NF-kappaB pathway activating mutations. Nat Commun (2017).8:14121; DOI: 10.1038/ncomms14121. (*equal contributions) (IF: 11.880)
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Lee YF, Kwok RCC, Wong ICK and Lui VW. The Pharmacogenomic Era in Asia: Potential roles and Challenges for Asian Pharmacists. Journal of Pharmacogenomics and Pharmacoproteomics. (2017) 8:164 (doi: 10.4172/2153-0645.1000164) (IF: 4.229)
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Hong B , Wang H, Wang W, Lui VW, Lin W. Combination treatment of RAD001 and BEZ235 exhibits synergistic antitumor activity via down-regulation of p-4E-BP1/Mcl-1 in small cell lung cancer. Oncotarget (2017) Jul 4;8(63):106486-106498. doi: 10.18632/oncotarget.18984 (IF:5.168)
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Bo Hong, Huogang Wang, Wei Wang, Vivian Wai Yan Lui, Wenchu Lin. Combination treatment of RAD001 and BEZ235 exhibits synergistic antitumor activity via down-regulation of p-4E-BP1/Mcl-1 in small cell lung cancer. Oncotarget (2017) Jul 4. doi: 10.18632/oncotarget.18984. [Epub ahead of print] (IF: 5.168)
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Fang J, Li X, Ma D, Liu X, Chen Y, Wang Y, Lui VWY, Xia J, Cheng B, Wang Z. Prognostic significance of tumor infiltrating immune cells in oral squamous cell carcinoma. BMC Cancer. (2017) May 26;17(1):375. doi: 10.1186/s12885-017-3317-2. (IF 3.288)
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Tsui PC, Lee Y-F, Liu ZWY, Ip LRH, Piao W, Chiang AKS, Lui VWY. An Update on Genomic-guided Therapies for Pediatric Solid Tumors. Future Oncology (2017) Jun;13(15):1345-1358. (IF: 2.129)
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Lee YF, Kwok RCC, Wong ICK and Lui VW. The Pharmacogenomic Era in Asia: Potential roles and Challenges for Asian Pharmacists. Journal of Pharmacogenomics and Pharmacoproteomics. (2017) 8:164 (doi: 10.4172/2153-0645.1000164) (IF:1.55)
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Peyser ND, Pendleton K, Goodings WE, Lui VW, Johnson DE, Grandis JR. Genomic and Transcriptomic Alterations Associated with STAT3 Activation in Head And Neck Cancer. PLos One (2016) Nov 17;11(11):e0166185. doi: 10.1371/journal.pone.0166185.
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Krista Roberta Voehoeft, Hoi Lam Ngan, Vivian Wai Yan Lui. The cylindromatosis (CYLD) gene and head and neck tumorigenesis. Cancers of the Head and Neck (In Press; 2016)
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Matthew L. Hedberg, Gerald Goh, Simion I. Chiosea, Julie E. Bauman, Maria L. Freilino, Yan Zeng, Lin Wang, Brenda B. Diergaarde, William E. Gooding, Vivian W. Y. Lui, Roy S. Herbst, Richard P. Lifton, and Jennifer R. Grandis. The Genetic Landscape of Head and Neck Cancer Recurrence and Metastasis. J. Clin. Investigation (2016) Jan 4;126(1):169-80. (IF: 12.575)
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Wen Y, Li H, Zeng Y, Wen W, Pendleton KP, Lui VW, Egloff AM, Grandis JR. MAPK1(E322K) mutation increased head and neck squamous cell carcinoma sensitivity to erlotinib through enhanced secretion of amphiregulin. Oncotarget (2016; In Press) (IF: 6.359)
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Li H, Wheeler S, Park Y, Ju Z, Thomas SM, Fichera M, Egloff AM, Lui VW, Duvvuri U, Bauman JE, Mills GB, Grandis JR. Proteomic Characterization of Head and Neck Cancer Patient-Derived Xenografts. Mol Cancer Res. (2016) Mar;14(3):278-86. (IF: 4.510)
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Eason Leong Yin Chan, Claudia Ho Yi Chin, Vivian Wai Yan Lui. An Update of ALK Inhibitors in Human Clinical Trials. Future Oncology (2016) Jan;12(1):71-81. (IF: 2.129)
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Van Allen EM*, Lui VW*, Egloff AM, Goetz EM, Li H, Johnson JT, Duvvuri U, Bauman JE, Stransky N, Zeng Y, Gilbert BR, Pendleton KP, Wang L, Chiosea S, Sougnez C, Wagle N, Zhang F, Du Y, Close D, Johnston PA, McKenna A, Carter SL, Golub TR, Getz G, Mills GB, Garraway LA, Grandis JR. Genomic correlate of exceptional erlotinib response in head and neck squamous cell carcinoma. JAMA Oncology. (2015). May 1;1(2):238-44. (*Co-first authorships)
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Yue GG, Lee JK, Li L, Chan K, Wong EC, Chan JW, Fung KP, Lui VW, Chiu PW, Lau CB. Andrographis paniculata elicits anti-invasion activities by suppressing TM4SF3 gene expression and by anoikis-sensitizatoin in esophageal cancer cells. Am J Cancer Res (2015) Nov 15;5(12):3570-87.(IF: 3.425)
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Yu Du, Noah D. Peyser, Hua Li, Vivian Lui, Xiao Xiao, Maciej Giefing, Timothy A. Chan, and Jennifer R. Grandis. Loss-of-function PTPRD mutations lead to increased STAT3 activation and sensitivity to STAT3 inhibition in head and neck cancer. PLos One (2015) Aug 12;10(8):e0135750. (IF: 3.234)
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Yau NK, Fong AY, Leung HF, Verhoeft KR, Lim QY, Lam WY, Wong IC, Lui VW. A Pan-Cancer review of ALK mutations: Implications for Carcinogenesis and Therapy. Current Cancer Drug Targets (2015)15(4):327-36 (IF: 3.522)
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Tsang CM, Cheung KCP, Cheung YC, Man K, Lui VW, Feng Y and Tsao SW. Berberine suppresses Id-1 expression and inhibits the growth and development of lung metastases in hepatocellular carcinoma. Biochim Biophys Acta (2015) Mar: 1852(3):541-51. (IF: 4.381)
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Sen M, Pollock NI, Black J, DeGrave KA, Wheeler S, Freilino ML, Joyce S, Lui VW, Zeng Y, Chiosea SI, Grandis JR. JAK Kinase Inhibition Abrogates STAT3 Activation and Head and Neck Squamous Cell Carcinoma Tumor Growth. Neoplasia (2015). Mar;17(3):256-64 (IF: 4.252)
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Wong EY, Wong SC, Chan CM, Lam EK, Ho LY, Lau CP, Au TC, Chan AK, Tsang CM, Tsao SW, Lui VW*, Chan AT. TP53-induced glycolysis and apoptosis regulator promotes proliferation and invasiveness of nasopharyngeal carcinoma cells. Oncology Letters (2015) Feb;9: 569-574. (*Corresponding author) (IF: 1.554)
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W Y Lam, Ariel CY Cheung, Christine KC Tung, Apple CM Yeung, Karry LK Ngai, Stephen SC Chim, Vivian Wai Yan Lui, Paul K S Chan, Stephen K W Tsui. miR-466 is a putative negative regulator of Coxsackie Virus and Adenovirus Receptor. FEBS Letters (2015) Jan 16;589(2):246-54. (IF: 4.237)
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Lui VW, Peyser ND, Ng PK, Hritz J, Zeng Y, Lu Y, Li H, Wang L, Gilbert BR, General IJ, Bahar I, Ju Z, Wang Z, Pendleton KP, Xiao X, Du Y, Vries JK, Hammerman PS, Garraway LA, Mills GB, Johnson DE, Grandis JR. Frequent mutation of receptor protein tyrosine phosphatases provides a mechanism for STAT3 hyperactivation in head and neck cancer. Proc Natl Acad Sci U S A. (2014) Jan 21;111(3):1114-9. (IF: 9.674)
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Li H, Wawrose JS, Gooding WE, Garraway LA, Lui VW, Peyser ND, Grandis JR. Genomic Analysis of Head and Neck Squamous Cell Carcinoma Cell Lines and Human Tumors: A Rational Approach to Preclinical Model Selection. Proc Natl Acad Sci U S A.(2014)Apr;12(4):571-82.(IF: 4.380)
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Lei Y, Lui VW, Grandis JR, Egloff AM. Identification of Mutations in the PYRIN-Containing NLR Genes (NLRP) in Head and Neck Squamous Cell Carcinoma. PLoS One. (2014) Jan 21;9(1):e85619. (IF: 3.234)
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Gao Y, Islam MS, Tian J, Lui VW and Xiao D. Inactivation of ATP citrate lyase by Cucurbitacin B: A bioactive compound from cucumber, inhibits prostate cancer growth. Cancer Lett (2014) Mar 29. pii: S0304-3835(14)00160-8.(IF: 5.621)
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Ma BB*, Lui VW*, Hui CW, Lau CP, Wong CH, Hui EP, Ng MH, Cheng SH, Tsao SW, Tsang CM, Cheung CS, Ho K, Chan AT. Preclinical evaluation of the mTOR-PI3K inhibitor BEZ235 in nasopharyngeal cancer models. Cancer Lett. (2014) Feb 1;343(1):24-32. (*Co-first authorship)(IF: 5.621)
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Wong ICK, Ng YK, Lui VW. Cancers of the Lung, and Head and Neck on the Rise: Perspectives of the Genotoxicity of Air Pollution. Chinese Journal of Cancer (2014) Oct 5;33(10):476-80. (IF: 1.935)
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Lui VW, Hedberg ML, Li H, Vangara BS, Pendleton K, Zeng Y, Lu Y, Zhang Q, Du Y, Gilbert BR, Freilino M, Sauerwein S, Peyser ND, Xiao D, Diergaarde B, Wang L, Chiosea S, Seethala R, Johnson JT, Kim S, Duvvuri U, Ferris RL, Romkes M, Nukui T, Kwok-Shing Ng P, Garraway LA, Hammerman PS, Mills GB, Grandis JR. Frequent mutation of the PI3K pathway in head and neck cancer defines predictive biomarkers. Cancer Discovery (2013) Jul;3(7):761-769. (IF: 19.929)
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Chiosea SI, Grandis JR, Lui VW, Diergaarde B, Maxwell JH, Ferris RL, Kim SW, Luvison A, Miller M, Nikiforova MN. PIK3CA, HRAS and PTEN in human papillomavirus positive oropharyngeal squamous cell carcinoma. BMC Cancer (2013) Dec 17;13(1):602 (IF: 3.362)
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Romick-Rosendale LE, Lui VW, Grandis JR, Wells SI. The Fanconi Anemia Pathway: Repairing the Link Between DNA Damage and Squamous Cell Carcinoma. Mutation Research (2013 Jan 17)Mar-Apr;743-744:78-88.(IF: 3.680)
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Ma BB*, Lui VW*, Hui CW, Lau CP, Wong CH, Hui EP, Ng MH, Tsao SW, Li Y, Chan AT. Preclinical evaluation of the AKT inhibitor MK-2206 in nasopharyngeal carcinoma cell lines. Invest New Drugs (2013) Jun;31(3):567-75. (IF: 2.919)
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Stabile LP*, He G*, Lui VW*, Thomas S, Henry C, Gubish CT, Joyce S, Quesnelle KM, Siegfried JM, Grandis JR. c-Src Activation Mediates Erlotinib Resistance in Head and Neck Cancer by Stimulating c-Met. Clinical Cancer Research (2013) Jan;19(2):380-92 (*Equal contributions) (IF: 8.722)
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Zhang G, Tsang CM, Deng W, Yip YL, Lui VW, Wong SC, Cheung AL, Hau PM, Zeng M, Lung ML, Chen H, Lo KW, Takada K, Tsao SW. Enhanced IL-6/IL-6R signaling promotes growth and malignant properties in EBV-infected premalignant and cancerous nasopharyngeal epithelial cells. PLoS One. (2013) May 1;8(5):e62284.(IF: 3.057)
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Ho Y, Tsao SW, Zeng M, Lui VW. STAT3 as a therapeutic target for Epstein-Barr Virus-associated Nasopharyngeal carcinoma (NPC). Cancer Letters (2013) Apr 28;330(2):141-9.(IF: 5.621)
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Ma BB*, Lui VW*, Cheung CS, Lau CP, Ho K, Hui EP, Tsui SK, Ng MH, Cheng SH, Ng PK, Tsao SW, Chan AT. Activity of the MEK inhibitor selumetinib (AZD6244; ARRY-142886) in nasopharyngeal cancer cell lines. Invest New Drugs.(2013) Feb;31(1):30-8. (IF: 3.281)
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Chan SL, Wong CH, Lau CP, Zhou Q, Hui CW, Lui VW, Ma BB, Chan AT, Yeo W. Preclinical evaluation of combined TKI-258 and RAD001 in hepatocellular carcinoma. Cancer Chemother Pharmacol (2013) Jun;71(6):1417-25.(IF: 2.769)
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Zhou Q, Wong CH, Lau CP, Hui CW, Lui VW, Chan SL, Yeo W. Enhanced Antitumor Activity with Combining Effect of mTOR Inhibition and in Microtubule-Stabilization in Hepatocellular Carcinoma. Int. J. of Hepatology (2013) 103830. (IF: 11.336) [1]
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Ng YK, Lau WS, Lui VW, Cheng AS, Ng PK, Tsui SK, Cheung YS, Lai PB. Full-length Mst1 exhibits growth promoting function in human hepatocellular carcinoma cells. FEBS Lett.(2013) Mar 1;587(5):496-503. (IF:4.237)
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Tsang CM, Cheung YC, Lui VW, Yip YL, Zhang G, Lin VW, Cheung KC, Feng Y, Tsao SW. Berberine suppresses tumorigenicity and growth of nasopharyngeal carcinoma cells by inhibiting STAT3 activation induced by tumor associated fibroblasts. BMC Cancer (2013) Dec 31;13:619.(IF: 3.362)
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Hong B, Lui VW*, Masumi H, Hui EP, Chan AT*. Targeting Tumor Hypoxia in Nasopharyngeal carcinoma. Head & Neck (2013) Jan;35(1):133-45. (*Co-Corresponding author) (IF: 2.641)
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Tsang CM, Yip YL, Lo KW, Deng W, To KF, Hau PM, Lau VM, Takada K, Lui VW, Lung ML, Chen H, Zeng M, Middeldorp JM, Cheung AL, Tsao SW. Cyclin D1 overexpression supports stable EBV infection in nasopharyngeal epithelial cells. Proc Natl Acad Sci U S A. (2012) Dec 11;109(50):E3473-82. (IF: 9.674)
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Duvvuri U, Shiwarski DJ, Xiao D, Bertrand C, Huang X, Edinger RS, Rock JR, Harfe BD, Henson BJ, Kunzelmann K, Schreiber R, Seethala RS, Egloff AM, Chen X, Lui VW, Grandis JR, Gollin SM. TMEM16A Induces MAPK and Contributes Directly to Tumorigenesis and Cancer Progression. Cancer Res (2012) Jul 1;72(13):3270-81. (IF: 9.329)
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Zhou Q, Lui VW*, Lau CP, Cheng SH, Ng MH, Cai Y, Chan SL, Yeo W. Sustained Antitumor Activity by Co-Targeting mTOR and the Microtubule with Temsirolimus/Vinblastine Combination in Hepatocellular Carcinoma. Biochem Pharmacol. (2012) May 1;83(9):1146-58 (*Co-Corresponding author) (IF: 5.009)
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Lui VW and Grandis JR. Primary Chemotherapy and Radiation as a Treatment Strategy for HPV-Positive Oropharyngeal Cancer. Head and Neck Pathology (2012) Jul;6 Suppl 1:91-7. (IF: 1.476)
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Lui VW*, Wong EY, Ho K, Ng PK, Lau CP, Tsui SK, Tsang CM, Tsao SW, Cheng SH, Ng MH, Ng YK, Lam EK, Hong B, Lo KW, Mok TS, Chan AT*, Mills GB. Inhibition of c-Met Downregulates TIGAR Expression and Reduces NADPH Production Leading to Cell Death. Oncogene (2011) Mar 3;30(9):1127-34. (IF: 7.932)
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Lui VW*, Yau DM*, Cheung CS, Wong SC, Chan AK, Zhou Q, Wong EY, Lau CP, Lam EK, Hui EP, Hong B, Hui CW, Chan AS, Ng PK, Ng YK, Lo KW, Tsang CM, Tsui SK, Tsao SW, Chan AT*. FGF8b Oncogene Mediates Proliferation and Invasion of Epstein-Barr Virus-associated Nasopharyngeal Carcinoma Cells: Implication for Viral-mediated FGF8b Upregulation. Oncogene (2011) Mar 31;30(13):1518-30. (*Co-Corresponding author) (IF: 7.932)
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Ng CF, Ng PK, Lui VW, Li J, Chan JY, Fung KP, Ng YK, Lai PB, Tsui SK. FHL2 exhibits anti-proliferative and anti-apoptotic activities in liver cancer cells. Cancer Lett. (2011) May 28;304(2):97-106.(IF: 5.621)
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Zhou Q, Lui VW* and Yeo W. Targeting the PI3K/AKT/mTOR Pathway in Hepatocellular Carcinoma. Future Oncol. (2011) Oct;7(10):1149-67.(Corresponding author) (IF: 2.129)
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Hong B*, Lui VW*, Hui EP, Ng MH, Cheng SH, Sung FL, Tsang CM, Tsao SW, Chan AT. Hypoxia-targeting by Tirapazamine (TPZ) Induces Preferential Growth Inhibition of Nasopharyngeal Carcinoma Cells with Chk1/2 Activation. Invest New Drugs (2011) Jun;29(3):401-10 (IF: 2.919)
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Vlantis AC, Lo CS, Chen GG, Ci Liang N, Lui VW, Wu K, Deng YF, Gong X, Lu Y, Tong MC, van Hasselt CA. Induction of laryngeal cancer cell death by ent-11-hydroxy-15-oxo-kaur-16-en-19-oic-acid. Head & Neck. (2010) Nov;32(11):1506-18. (IF: 2.641)
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Yang W, Cai Q, Lui VW, Everley PA, Kim J, Bhola N, Quesnelle KM, Zetter B, Steen H, Freeman MR, Grandis JR. Quantitative Proteomics Analysis Reveals Molecular Networks Regulated by Epidermal Growth Factor Receptor Level in Head and Neck Cancer. J. Proteome Research (Apr 28, 2010). (IF: 4.245)
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Hong B*, Lui VW*, Hui EP, Lu Y, Leung HS, Wong EY, Cheng SH, Ng MH, Mills GB, Chan AT. Reverse Phase Protein Array Identifies Novel Anti-invasion Mechanisms of YC-1. Biochemical Pharmacology (2010) Mar 15;79(6):842-52. (IF: 5.009)
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Lui VW*, Lau CP*, Cheung CS, Ho K, Ng MH, Cheng SH, Hong B, Tsao SW, Tsang CM, Lei KI, Yamasaki Y, Mita A, Chan AT. An RNA-directed Nucleoside Anti-metabolite, 1-(3-C-ethynyl-beta-D-ribo-pentofuranosyl)cytosine (ECyd), Elicits Antitumor Effect Via TP53-induced Glycolysis And Apoptosis Regulator (TIGAR) Downregulation. Biochemical Pharmacology (2010) Jun 15;79(12):1772-80. (IF: 5.009)
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Pang JC, Li KK, Lau KM, Ng YL, Wong J, Chung NY, Li HM, Chui YL, Lui VW, Chen ZP, Chan DT, Poon WS, Wang Y, Mao Y, Zhou L, Ng HK. KIAA0495/PDAM is frequently downregulated in oligodendroglial tumors and its knockdown by siRNA induces cisplatin resistance in glioma cells. Brain Pathology (Apr 16, 2010). (IF: 3.840)
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Ng YK, Wong EY, Lau CP, Chan JP, Wong SC, Chan AS, Kwan MP, Tsao SW, Tsang CM, Lai PB, Chan AT, Lui VW. K252a Induces Anoikis-sensitization with Suppression of Cellular Migration in Epstein-Barr Virus (EBV)-associated Nasopharyngeal Carcinoma Cells. Invest New Drugs. (2010) Aug 7. (Corresponding author). (IF: 3.281)
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Ma BB*, Lui VW*, Poon FF, Wong SC, To KF, Wong E, Chen H, Lo KW, Tao Q, Ng MH, Cheng SH, Chan AT. Preclinical activity of gefitinib in non-keratinizing nasopharyngeal carcinoma cell lines and biomarkers of response. Invest New Drugs. (2010) Jun;28(3):326-33. (IF: 3.281)
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Lui VW, Lau CP, Ho K, Ng MH, Cheng SH, Tsao SW, Tsang CM, Lei KI, Chan AT, Mok TS. Anti-invasion, Anti-proliferation and Anoikis-sensitization Activities of Lapatinib in Nasopharyngeal Carcinoma Cells. Invest New Drugs. (2010) June 23. (Corresponding author) (IF: 3.281)
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Ma BB, Sung F, Tao Q, Poon FF, Lui VW, Yeo W, Chan SL, Chan AT. The preclinical activity of the histone deacetylase inhibitor PXD101 (belinostat) in hepatocellular carcinoma cell lines. Invest New Drugs (2010) Apr;28(2):107-14. (IF: 3.281)
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Hui EP*, Lui VW*, Wong CS, Ma BB, Lau CP, Cheung CS, Ho K, Cheng SH, Ng MH, Chan AT. Preclinical evaluation of sunitinib as a single agent or in combination with chemotherapy in nasopharyngeal carcinoma. Investigational New Drugs (May 15, 2010). (IF: 3.281)
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Ma BB*, Lui VW*, Hui EP, Lau CP, Ho K, Ng MH, Cheng SH, Tsao SW, Chan AT. The activity of the mTOR inhibitor RAD001 (everolimus) in nasopharyngeal carcinoma cell lines. Invest New Drugs. (2010) Aug;28(4):413-20. (IF: 3.281)
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Wong JH*, Lui VW*, Umezawa K, Ho Y, Wong EY, Ng MH, Cheng SH, Tsang CM, Tsao SW, Chan AT. A Small Molecule Inhibitor of NF-κB, Dehydroxymethylepoxyquinomicin (DHMEQ), Suppresses Growth and Invasion of Nasopharyngeal Carcinoma (NPC) Cells. Cancer Letters (2010) Jan 1;287(1):23-32. (IF: 5.621)
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Lui VW*, Yau DM*, Wong EY, Ng YK, Lau CP, Ho Y, Chan JP, Hong B, Ho K, Cheung CS, Tsang CM, Tsao SW, Chan AT. Cucurbitacin I Elicits Anoikis-sensitization, Inhibits Cellular Invasion and In Vivo Tumor Formation Ability of Nasopharyngeal Carcinoma Cells. Carcinogenesis (2009) Dec;30(12):2085-94. (IF: 5.334)
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Lui VW*, Wong EY*, Ho Y, Hong B, Wong SC, Tao Q, Choi GC, Au TC, Ho K, Yau DM, Ma BB, Hui EP, Chan AS, Tsang CM, Tsao SW, Grandis JR, Chan AT. STAT3 Activation Contributes Directly to Epstein-Barr virus-mediated Invasiveness of Nasopharyngeal cancer (NPC) Cells In Vitro. Int. J Cancer (2009) Oct 15;125(8):1884-93. (IF: 5.085)
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Lai SY, Koppikar P, Thomas SM, Childs EE, Egloff AM, Seethala RR, Branstetter BF, Gooding WE, Muthukrishnan A, Mountz JM, Lui VW, Shin DM, Agarwala SS, Johnson R, Couture LA, Myers EN, Johnson JT, Mills G, Argiris A, Grandis JR. Intratumoral Epidermal Growth Factor Receptor Antisense DNA Therapy in Head and Neck Cancer: First Human Application and Potential Antitumor Mechanisms. J Clin Oncol. (2009) Mar 10;27(8):1235-42. (IF: 18.428)
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Koppikar P, Lui VW, Man D, Xi S, Chai RL, Nelson E, Tobey AB, Grandis JR. Constitutive Activation of STAT5 Contributes to Tumor Growth, Epithelial-Mesenchymal Transition (EMT), and Resistance to Epidermal Growth Factor Receptor Targeting. Clinical Cancer Research (2008) Dec 1;14(23):7682-90. (IF: 8.722)
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Mok Tony S., Choi Eve, Wong Cesar, Leung Linda, Lui Philip, To Kai Fai, Lam Kwok Chi, Lui Vivian. "To overcome T790M associated EGFR TKI resistance by addition of mono-clonal antibodies against HER-1 and/or Her-2 receptors". Journal of Thoracic Oncology (2007) Aug;Vol.2 no.8: 508. (Corresponding author). (IF: 5.282)
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Lui VW, Boehm AL, Koppikar P, Leeman RJ, Johnson D, Ogagan M, Childs E, Freilino M, Grandis JR. Antiproliferative Mechanisms of a Transcription Factor Decoy Targeting STAT3: the Role of STAT1. Molecular Pharmacology (2007) May;71(5):1435-43. (IF: 4.128)
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Zhang Q, Bhola NE, Lui VW, Siwak DR, Thomas SM, Gubish CT, Siegfried JM, Mills GB, Shin D, Grandis JR. Anti-tumor mechanisms of combined GRPR and EGFR targeting in head and neck cancer. Molecular Cancer Therapeutics (2007) April, 6 (4):1414-1424. (IF: 5.683)
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Leeman RJ, Lui VW, Grandis JR. STAT3 as a Therapeutic target in head and neck cancer. Expert Opinion on Biological Therapy (2006) Mar;6(3):231-41. (IF: 3.438)
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Zhang Q, Thomas SM, Lui VW, Xi S, Siegfried JM, Fan H, Smithgall TE, Mills GB, Grandis JR. Phosphorylation of TNF-{alpha} converting enzyme by gastrin-releasing peptide induces amphiregulin release and EGF receptor activation. Proc Natl Acad Sci U S A (2006) May 2;103(18):6901-6. (IF: 9.432)
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Thomas SM, Grandis JR, Wentzel AL, Gooding WE, Lui VW, Siegfried JM. Gastrin-releasing peptide receptor mediates activation of the epidermal growth factor receptor in lung cancer cells. Neoplasia (2005) Apr;7(4):426-31.(IF: 4.252)
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Lui VW, Wentzel AL, Xiao D, Lew KL, Singh SV, Grandis JR. Requirement of a carbon spacer in benzyl isothiocynate-mediated cytotoxicity and MAPK activation in head and neck squamous cell carcinoma. Carcinogenesis (2003) Oct; 24(10):1705-12. (IF: 5.334)
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Lui VW, Thomas SM, Zhang Q, Wentzel AL, Siegfried JM, Li JY, Grandis JR. Mitogenic effects of gastrin-releasing peptide in head and neck squamous cancer cells are mediated by activation of the epidermal growth factor receptor. Oncogene (2003) Sep 18; 22(40): 6183-93. (IF: 8.459)
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Niwa H, Wentzel AL, Li M, Gooding WE, Lui VW, Grandis JR. Antitumor effects of Epidermal growth factor receptor antisense oligonucleotides in combination with docetaxel in squamous cell carcinoma of the head and neck. Clin Cancer Res.(2003) Oct 15; 9(13): 5028-5035.(IF: 8.722)
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Lui VWY and Huang L. Non-viral vectors for cancer gene therapy. In: Pharmaceutical Gene Delivery Systems, Drug and the Pharmaceutical Sciences Series, Marcel Dekker, Inc., NY. (2003) Vol 131 Ch 11: 279-319. (Peer-reviewed Book Chapter)
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Lango MN, Dyer KF, Lui VW, Gooding WE, Gubish C, Siegfried JM, Grandis JR. Gastrin-releasing peptide receptor-mediated autocrine growth in Squamous cell carcinoma of the head and neck. J. Natl. Cancer Inst. (2002) Mar 6; 94(5): 375-83. (IF: 11.370)
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Lui VW, Falo LD Jr, Huang L. Systemic production of IL-12 by naked DNA mediated gene transfer: toxicity and attenuation of transgene expression in vivo. The Journal of Gene Medicine (2001) Jul-Aug;3(4):384-93. (IF: 3.246)
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He YK, Lui VW, Baar J, Wang L, Shurin M, Almonte C, Watkins SC, Huang L. Potentiation of E7 antisense RNA-induced antitumor immunity by co-delivery of IL-12 gene in HPV 16 DNA-positive mouse tumor. Gene Therapy (1998) Nov;5(11):1462-71. (IF: 3.242)
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Dou QP and Lui VW. Failure to dephosphorylate Retinoblastoma protein in drug-resistance cells. Cancer Research. (1995) Nov 15;55(22):5222-5. (IF: 9.329)